Electroencephalogram in anticonvulsant-induced folate deficiency.

Plasma and erythrocyte folate in iron deficiency and folate deficiency.

I T WAS SHOWN by Toennies et a!.1 that most of the blood folate is within the erythrocytes. The erythrocyte folate level may be reduced in either folate or vitamin B12 deficiency,25 and it can be used as an index of the folate content of body tissues.4 The present paper reports that in iron deficiency anemia there are abnormalities in distribution of folate between plasma and erythrocytes which...

ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS

35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the ...

Folate deficiency in premature infants.

Zuelzer and Ogden first clearly defined the syndrome of megaloblastic anaemia in infants, which responds to folic acid, as long ago as 1946. They concluded: 'In an analysis of etiologic conditions, infections and nutritional deficiencies appear significant while age, race and possibly prematurity and maternal anemia are predisposing factors'. 5 ofthe 25 infants they described had been born prem...

Folate deficiency in chronic pancreatitis.

Cerebral folate deficiency syndrome.

to the editor: Ramaekers et al. (May 12 issue)1 report 28 patients with the cerebral folate deficiency syndrome characterized by decreased levels of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid caused by autoantibodies’ blocking of folate transport into the brain. The patients benefited from folinic acid supplementation. The clinical features of this syndrome fit with other neuro...